PLEKHF2

Across TCGA patient cohorts, PLEKHF2 protein abundance is significantly associated with the RNA expression of many other genes, with 11,970 significant associations in total. BRCA shows the largest number of these associations.

The most reproducible PLEKHF2-associated genes across cancer lineages are SPAG1, WWP1, and UCHL1. Each is linked with PLEKHF2 in more than 5 cancer types. Because this analysis shows association rather than direction, both PLEKHF2-to-partner and partner-to-PLEKHF2 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, PLEKHF2 versus SPAG1 in OV, with a Pearson correlation of 0.42.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PLEKHF2→partner) and Y-score (partner→PLEKHF2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	SPAG1 →	+1.303	+0.482	<.001	.002	3	6
BRCA	WWP1 →	+1.178	+0.365	<.001	<.001	3	5
OV	UCHL1 →	-2.095	-0.472	<.001	.001	3	5
BRCA	ANKRD46 →	+0.640	+0.299	.002	.007	3	5
OV	STK3 →	+0.757	+0.512	<.001	.003	3	4
OV	DBN1 →	-1.146	-0.517	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 11,970 associations by consensus.

PLEKHF2 vs SPAG1 — OV

Explore this scatter interactively →