PLEKHF2

Across TCGA patient cohorts, PLEKHF2 mutation is significantly associated with the RNA expression of many other genes, with 1,487 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PLEKHF2-associated genes across cancer lineages are RNA5SP372, SNORD3B-2, and ACOD1. Each is linked with PLEKHF2 in more than 1 cancer types. Because this analysis shows association rather than direction, both PLEKHF2-to-partner and partner-to-PLEKHF2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNA5SP372 grouped by PLEKHF2-low versus PLEKHF2-high in BLCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PLEKHF2→partner) and Y-score (partner→PLEKHF2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLCA	RNA5SP372 →	+0.653	+4.238	<.001	.008	3	2
UCEC	SNORD3B-2 →	+0.480	+1.673	.004	.007	3	2
UCEC	ACOD1 →	+0.105	+1.930	.004	.002	3	2
BRCA	RN7SL82P →	+0.128	+7.731	<.001	.009	3	1
UCEC	RPS10-NUDT3 →	+0.237	+2.839	<.001	<.001	3	1
UCEC	IGKV1OR2-118 →	+0.167	+1.666	.002	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,487 associations by consensus.

RNA5SP372 by PLEKHF2 expression — BLCA

Explore this box plot interactively →