PLEKHD1

Across TCGA patient cohorts, PLEKHD1 RNA expression is significantly associated with the protein abundance of many other proteins, with 10,837 significant associations in total. BRCA shows the largest number of these associations.

The most reproducible PLEKHD1-associated proteins across cancer lineages are CBX6, CACNA2D2, and DOK3. Each is linked with PLEKHD1 in more than 3 cancer types. Because this analysis shows association rather than direction, both PLEKHD1-to-partner and partner-to-PLEKHD1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, PLEKHD1 versus CBX6 in BRCA, with a Pearson correlation of 0.27.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (PLEKHD1→partner) and Y-score (partner→PLEKHD1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	CBX6 →	+0.430	+0.787	.001	.002	3	4
BRCA	CACNA2D2 →	+0.857	+0.931	<.001	<.001	3	4
GBM	DOK3 →	-0.381	-0.281	.005	.008	3	4
BRCA	USF2 →	+0.318	+1.000	.007	.002	3	3
BRCA	XRCC1 →	+0.375	+1.224	<.001	<.001	3	3
LSCC	BLMH →	+0.321	+0.486	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 10,837 associations by consensus.

PLEKHD1 vs CBX6 — BRCA

Explore this scatter interactively →