PLEKHD1

Across TCGA patient cohorts, PLEKHD1 mutation is significantly associated with the total protein of many other genes, with 19 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PLEKHD1-associated genes across cancer lineages are ACC1, Di-Ras3, and EGFR_pY1068. Each is linked with PLEKHD1 in more than 1 cancer types. Because this analysis shows association rather than direction, both PLEKHD1-to-partner and partner-to-PLEKHD1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ACC1 grouped by PLEKHD1-low versus PLEKHD1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PLEKHD1→partner) and Y-score (partner→PLEKHD1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ACC1 →	+0.362	+2.820	.015	.035	3	2
UCEC	Di-Ras3 →	-0.187	-3.459	.002	.005	3	2
UCEC	EGFR_pY1068 →	-0.242	-2.321	.019	.033	3	1
UCEC	JNK2 →	+0.246	+1.884	.002	.030	3	1
UCEC	Ku80 →	+0.412	+2.335	<.001	.003	3	1
UCEC	Notch1 →	+0.178	+3.335	.002	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 19 associations by consensus.

ACC1 by PLEKHD1 expression — UCEC

Explore this box plot interactively →