PLEKHB2

Across TCGA patient cohorts, PLEKHB2 protein abundance is significantly associated with the RNA expression of many other genes, with 5,300 significant associations in total. GBM shows the largest number of these associations.

The most reproducible PLEKHB2-associated genes across cancer lineages are PRKD3, PGBD1, and ZNF705E. Each is linked with PLEKHB2 in more than 2 cancer types. Because this analysis shows association rather than direction, both PLEKHB2-to-partner and partner-to-PLEKHB2 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, PLEKHB2 versus PRKD3 in UCEC, with a Pearson correlation of -0.28.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PLEKHB2→partner) and Y-score (partner→PLEKHB2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PRKD3 →	-0.530	-0.592	.001	<.001	3	3
UCEC	PGBD1 →	-0.731	-0.553	<.001	<.001	3	3
GBM	ZNF705E →	-0.350	-0.351	<.001	<.001	3	3
UCEC	DEFB130C →	-0.772	-0.633	.008	<.001	3	3
UCEC	EVC →	-0.651	-0.392	.004	.003	3	3
GBM	C19orf44 →	-0.517	-0.365	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,300 associations by consensus.

PLEKHB2 vs PRKD3 — UCEC

Explore this scatter interactively →