PLEKHB2

Across TCGA patient cohorts, PLEKHB2 mutation is significantly associated with the RNA expression of many other genes, with 1,165 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PLEKHB2-associated genes across cancer lineages are NUTF2P8, PLSCR5-AS1, and MIR7854. Each is linked with PLEKHB2 in more than 1 cancer types. Because this analysis shows association rather than direction, both PLEKHB2-to-partner and partner-to-PLEKHB2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, NUTF2P8 grouped by PLEKHB2-low versus PLEKHB2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PLEKHB2→partner) and Y-score (partner→PLEKHB2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	NUTF2P8 →	+0.093	+2.304	<.001	.005	3	2
BLCA	PLSCR5-AS1 →	+0.084	+7.640	<.001	.009	3	2
SKCM	MIR7854 →	+0.309	+4.282	<.001	.009	3	2
LUSC	TTTY2 →	+0.009	+7.924	<.001	.008	3	2
UCEC	GM2AP2 →	+0.163	+1.839	<.001	.003	3	2
SKCM	RN7SL831P →	+0.209	+5.634	<.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,165 associations by consensus.

NUTF2P8 by PLEKHB2 expression — UCEC

Explore this box plot interactively →