PLEKHB2

Across TCGA patient cohorts, PLEKHB2 mutation is significantly associated with the total protein of many other genes, with 19 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PLEKHB2-associated genes across cancer lineages are Caspase-7-cleavedD198, EGFR_pY1068, and ER-alpha. Each is linked with PLEKHB2 in more than 1 cancer types. Because this analysis shows association rather than direction, both PLEKHB2-to-partner and partner-to-PLEKHB2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by PLEKHB2-low versus PLEKHB2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PLEKHB2→partner) and Y-score (partner→PLEKHB2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Caspase-7-cleavedD198 →	+0.796	+3.169	.002	.018	3	2
UCEC	EGFR_pY1068 →	-0.274	-2.115	.012	.019	3	1
UCEC	ER-alpha →	-0.774	-3.156	.031	.018	3	1
UCEC	IGFBP2 →	-0.817	-2.115	.003	.019	3	1
UCEC	MEK1 →	+0.470	+3.459	.003	.005	3	1
UCEC	MSH2 →	-0.463	-2.558	<.001	.010	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 19 associations by consensus.

Caspase-7-cleavedD198 by PLEKHB2 expression — UCEC

Explore this box plot interactively →