PLEKHB2

Across TCGA cell cohorts, PLEKHB2 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,527 significant associations in total. CNS shows the largest number of these associations.

The most reproducible PLEKHB2-associated GO terms across cancer lineages are Regulation of cellular response to hypoxia, Cytosolic transport, and Peptidyl-serine phosphorylation. Each is linked with PLEKHB2 in more than 12 cancer types. Because this analysis shows association rather than direction, both PLEKHB2-to-partner and partner-to-PLEKHB2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of cellular response to hypoxia grouped by PLEKHB2-low versus PLEKHB2-high in OESOPHAGUS.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PLEKHB2→partner) and Y-score (partner→PLEKHB2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	Regulation of cellular response to hypoxia →	+0.080	+0.732	.004	.002	3	13
SOFT_TISSUE	Cytosolic transport →	+0.065	+1.166	<.001	<.001	3	11
UPPER_AERODIGESTIVE_TRACT	Peptidyl-serine phosphorylation →	+0.070	+0.939	<.001	.003	3	11
UPPER_AERODIGESTIVE_TRACT	Phosphatidylinositol biosynthetic process →	+0.058	+0.823	<.001	<.001	3	11
BONE	Endosomal vesicle fusion →	+0.112	+0.774	.001	.007	3	11
SKIN	Peptidyl-serine modification →	+0.072	+0.702	<.001	.004	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,527 associations by consensus.

Regulation of cellular response to hypoxia by PLEKHB2 expression — OESOPHAGUS

Explore this box plot interactively →