PLEKHA6

Across TCGA pan-cancer cohorts, PLEKHA6 mass-spec protein differs between tumor and matched normal tissue in 4 of 18 cancer types tested, making tumor–normal expression one of PLEKHA6’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where PLEKHA6 mass-spec protein is repressed in tumor relative to normal tissue. In most cancer types PLEKHA6 is over-expressed in tumor, although a few such as HNSC and CCRCC show the opposite, repressed pattern.

HNSC, CCRCC, and LUAD are the cancer types where PLEKHA6 tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in PLEKHA6 mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	All	IV	−1.088	<.001	12	view →
CCRCC	Female	II,III,IV	−1.012	<.001	12	view →
LUAD	Female	All	+0.492	<.001	9	view →
LSCC	Male	III,IV	−0.809	<.001	8	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 4 strongest of 4 lineages.

PLEKHA6–HNSC

Open the HNSC breakdown →