PLEKHA5

Across TCGA patient cohorts, PLEKHA5 mutation is significantly associated with the total protein of many other genes, with 51 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PLEKHA5-associated genes across cancer lineages are STAT3_pY705, p38-MAPK_pT180_Y182, and Src_pY527. Each is linked with PLEKHA5 in more than 3 cancer types. Because this analysis shows association rather than direction, both PLEKHA5-to-partner and partner-to-PLEKHA5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, STAT3_pY705 grouped by PLEKHA5-low versus PLEKHA5-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PLEKHA5→partner) and Y-score (partner→PLEKHA5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	STAT3_pY705 →	-0.398	-2.060	<.001	.001	3	4
UCEC	p38-MAPK_pT180_Y182 →	-0.562	-2.308	<.001	<.001	3	3
UCEC	Src_pY527 →	-0.311	-1.896	.026	.015	3	3
UCEC	4E-BP1_pT37_T46 →	-0.308	-1.794	.011	.024	3	3
UCEC	MEK1 →	+0.446	+2.999	<.001	<.001	3	2
UCEC	4E-BP1 →	+0.348	+2.614	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 51 associations by consensus.

STAT3_pY705 by PLEKHA5 expression — UCEC

Explore this box plot interactively →