PLEKHA5

Across TCGA cell cohorts, PLEKHA5 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,191 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible PLEKHA5-associated GO terms across cancer lineages are Regulation of SREBP signaling pathway, Vacuolar transport, and Protein localization to vacuole. Each is linked with PLEKHA5 in more than 7 cancer types. Because this analysis shows association rather than direction, both PLEKHA5-to-partner and partner-to-PLEKHA5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of SREBP signaling pathway grouped by PLEKHA5-low versus PLEKHA5-high in BREAST.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PLEKHA5→partner) and Y-score (partner→PLEKHA5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	Regulation of SREBP signaling pathway →	+0.078	+1.260	<.001	<.001	3	8
BLOOD_Lymphoma	Vacuolar transport →	+0.048	+2.025	<.001	<.001	3	7
SOFT_TISSUE	Protein localization to vacuole →	+0.045	+1.234	.002	.002	3	7
OVARY	Cold acclimation →	+0.142	+1.217	<.001	<.001	3	7
OVARY	Adiponectin-activated signaling pathway →	+0.113	+1.219	<.001	<.001	3	7
BONE	Protein targeting to lysosome →	+0.090	+0.889	.001	.006	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,191 associations by consensus.

Regulation of SREBP signaling pathway by PLEKHA5 expression — BREAST

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