PLEKHA5

Across TCGA cell cohorts, PLEKHA5 mutation is significantly associated with the RNA expression of many other genes, with 1,083 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PLEKHA5-associated genes across cancer lineages are C12orf65, LARS1, and PGAP4. Each is linked with PLEKHA5 in more than 1 cancer types. Because this analysis shows association rather than direction, both PLEKHA5-to-partner and partner-to-PLEKHA5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, C12orf65 grouped by PLEKHA5-low versus PLEKHA5-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PLEKHA5→partner) and Y-score (partner→PLEKHA5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	C12orf65 →	+0.414	+3.252	.002	.002	3	2
LARGE_INTESTINE	LARS1 →	+0.520	+2.743	.001	.001	3	2
LARGE_INTESTINE	PGAP4 →	+1.104	+3.389	.002	.001	3	2
LARGE_INTESTINE	ZCCHC8 →	+0.612	+3.169	<.001	.009	3	2
BLOOD_Lymphoma	TPSAB1 →	+0.229	+3.700	<.001	.009	3	1
BLOOD_Lymphoma	ZNF676 →	+0.692	+3.954	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,083 associations by consensus.

C12orf65 by PLEKHA5 expression — LARGE_INTESTINE

Explore this box plot interactively →