PLEKHA4

Across TCGA patient cohorts, PLEKHA4 RNA expression is significantly associated with the protein abundance of many other proteins, with 11,360 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible PLEKHA4-associated proteins across cancer lineages are PLEKHA4_S575, SYNPO, and PLEKHA4_S164. Each is linked with PLEKHA4 in more than 9 cancer types. Because this analysis shows association rather than direction, both PLEKHA4-to-partner and partner-to-PLEKHA4 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, PLEKHA4 versus PLEKHA4_S575 in OV, with a Pearson correlation of 0.54.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (PLEKHA4→partner) and Y-score (partner→PLEKHA4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	PLEKHA4_S575 →	+0.972	+0.992	<.001	<.001	3	10
HNSC	SYNPO →	+0.417	+0.794	<.001	.002	3	7
OV	PLEKHA4_S164 →	+1.427	+1.079	.002	.007	3	7
OV	PLEKHA4_S241 →	+0.754	+1.069	.001	.004	3	7
OV	PLEKHA4_T296 →	+0.707	+0.750	.008	.001	2	8
COAD	PLEKHA4_T271 →	+0.995	+1.360	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 11,360 associations by consensus.

PLEKHA4 vs PLEKHA4_S575 — OV

Explore this scatter interactively →