PLEKHA4

Across TCGA patient cohorts, PLEKHA4 protein abundance is significantly associated with the RNA expression of many other genes, with 6,799 significant associations in total. GBM shows the largest number of these associations.

The most reproducible PLEKHA4-associated genes across cancer lineages are LIF, C1S, and SULF2. Each is linked with PLEKHA4 in more than 4 cancer types. Because this analysis shows association rather than direction, both PLEKHA4-to-partner and partner-to-PLEKHA4 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, PLEKHA4 versus LIF in UCEC, with a Pearson correlation of 0.31.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PLEKHA4→partner) and Y-score (partner→PLEKHA4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	LIF →	+1.514	+0.341	<.001	.008	3	5
GBM	C1S →	+0.795	+0.271	<.001	<.001	3	4
BRCA	SULF2 →	+1.301	+0.674	<.001	<.001	3	4
UCEC	VDR →	+0.767	+0.513	.002	<.001	3	4
UCEC	HRH1 →	+0.910	+0.448	<.001	<.001	3	4
LSCC	MEDAG →	+0.816	+0.396	.003	.001	2	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,799 associations by consensus.

PLEKHA4 vs LIF — UCEC

Explore this scatter interactively →