PLEKHA4

Across TCGA patient cohorts, PLEKHA4 mutation is significantly associated with the RNA expression of many other genes, with 1,483 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PLEKHA4-associated genes across cancer lineages are ZCCHC4, LCORL, and EXOSC9. Each is linked with PLEKHA4 in more than 2 cancer types. Because this analysis shows association rather than direction, both PLEKHA4-to-partner and partner-to-PLEKHA4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ZCCHC4 grouped by PLEKHA4-low versus PLEKHA4-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PLEKHA4→partner) and Y-score (partner→PLEKHA4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ZCCHC4 →	+0.312	+1.949	.003	.001	3	3
UCEC	LCORL →	+0.320	+2.938	.009	<.001	3	3
UCEC	EXOSC9 →	+0.423	+2.386	.001	.002	3	3
SKCM	ZCCHC9 →	+0.493	+2.347	.002	.002	3	3
SKCM	ITGB3BP →	+0.438	+2.434	.008	.001	3	3
SKCM	HSPB11 →	+0.313	+2.189	.007	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,483 associations by consensus.

ZCCHC4 by PLEKHA4 expression — UCEC

Explore this box plot interactively →