PLEKHA4

Across TCGA cell cohorts, PLEKHA4 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,424 significant associations in total. CNS shows the largest number of these associations.

The most reproducible PLEKHA4-associated GO terms across cancer lineages are Negative regulation of protein kinase activity by regulation of protein phosphorylation, Response to water, and Negative regulation of myoblast fusion. Each is linked with PLEKHA4 in more than 8 cancer types. Because this analysis shows association rather than direction, both PLEKHA4-to-partner and partner-to-PLEKHA4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of protein kinase activity by regulation of protein phosphorylation grouped by PLEKHA4-low versus PLEKHA4-high in SOFT_TISSUE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PLEKHA4→partner) and Y-score (partner→PLEKHA4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	Negative regulation of protein kinase activity by regulation of protein phosphorylation →	+0.108	+1.298	<.001	<.001	3	9
OESOPHAGUS	Response to water →	+0.148	+1.541	.007	.002	3	9
BREAST	Negative regulation of myoblast fusion →	+0.094	+1.867	<.001	<.001	3	8
BREAST	Negative regulation of syncytium formation by plasma membrane fusion →	+0.108	+2.404	<.001	<.001	3	8
UPPER_AERODIGESTIVE_TRACT	Positive regulation of chromatin binding →	+0.198	+1.600	<.001	.001	3	8
UPPER_AERODIGESTIVE_TRACT	Positive regulation of autophagy →	+0.050	+1.155	<.001	.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,424 associations by consensus.

Negative regulation of protein kinase activity by regulation of protein phosphorylation by PLEKHA4 expression — SOFT_TISSUE

Explore this box plot interactively →