PLEKHA3P1

Across TCGA pan-cancer cohorts, PLEKHA3P1 RNA is linked to patient survival in 25 of 34 cancer types, making it the most broadly survival-associated PLEKHA3P1 data layer.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher PLEKHA3P1 RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated PLEKHA3P1 expression acts as an unfavorable survival marker, although some lineages such as LUAD and UCEC show a favorable association.

LUAD, UCEC, and SKCM are the cancer types where PLEKHA3P1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	DFS	Median	All	0.733	0.602	<.001	77	view →
UCEC	DFS	Quartile	III,IV	0.923	0.733	.006	66	view →
SKCM	OS	Tertile	II,III,IV	0.370	0.217	.001	59	view →
UCS	DFS	Median	IV	0.952	0.367	.001	54	view →
DLBC	DFS	Median	All	0.666	0.963	.002	47	view →
ESCA	DFS	Quartile	All	0.641	0.359	.003	46	view →
KIRC	DFS	Median	All	0.903	0.839	.006	35	view →
THCA	DFS	Median	All	0.893	0.765	.004	28	view →
CHOL	DFS	Median	All	0.763	0.121	.001	21	view →
MESO	DFS	Median	III,IV	0.500	0.312	.018	20	view →
OV	OS	Tertile	III,IV	0.770	0.882	.001	20	view →
LAML	DFS	Median	All	0.476	0.669	.002	20	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 25 lineages.

PLEKHA3P1–LUAD (DFS)

Open the LUAD breakdown →