PLEKHA3

Across TCGA patient cohorts, PLEKHA3 RNA expression is significantly associated with the protein abundance of many other proteins, with 16,131 significant associations in total. PDAC shows the largest number of these associations.

The most reproducible PLEKHA3-associated proteins across cancer lineages are PRKRA, SCRN3, and NELFCD. Each is linked with PLEKHA3 in more than 5 cancer types. Because this analysis shows association rather than direction, both PLEKHA3-to-partner and partner-to-PLEKHA3 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, PLEKHA3 versus PRKRA in HNSC, with a Pearson correlation of 0.51.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (PLEKHA3→partner) and Y-score (partner→PLEKHA3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	PRKRA →	+0.277	+0.522	<.001	<.001	3	6
BRCA	SCRN3 →	+0.318	+0.474	<.001	<.001	3	4
HNSC	NELFCD →	+0.312	+0.696	<.001	<.001	3	4
BRCA	RO60 →	+0.266	+0.320	<.001	.003	2	5
HNSC	ABI2 →	+0.293	+0.628	.008	.001	3	4
LSCC	RPS6_S240 →	-0.714	-0.522	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 16,131 associations by consensus.

PLEKHA3 vs PRKRA — HNSC

Explore this scatter interactively →