PLEKHA3

Across TCGA patient cohorts, PLEKHA3 mutation is significantly associated with the total protein of many other genes, with 6 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PLEKHA3-associated genes across cancer lineages are Annexin-1, VHL, and C-Raf. Each is linked with PLEKHA3 in more than 1 cancer types. Because this analysis shows association rather than direction, both PLEKHA3-to-partner and partner-to-PLEKHA3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Annexin-1 grouped by PLEKHA3-low versus PLEKHA3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PLEKHA3→partner) and Y-score (partner→PLEKHA3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Annexin-1 →	+0.870	+3.019	.001	.019	3	1
UCEC	VHL →	-1.047	-3.000	.003	.036	3	1
UCEC	C-Raf →	+0.236	+3.169	.001	.019	3	1
UCEC	Di-Ras3 →	-0.248	-3.000	.001	.036	2	1
UCEC	EGFR_pY1068 →	-0.418	-3.321	.001	.010	1	1
UCEC	4E-BP1 →	+0.434	+3.321	.002	.010	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 6 associations by consensus.

Annexin-1 by PLEKHA3 expression — UCEC

Explore this box plot interactively →