PLEKHA3

Across TCGA cell cohorts, PLEKHA3 RNA expression is significantly associated with the RNA expression of many other genes, with 12,606 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible PLEKHA3-associated genes across cancer lineages are MAP3K2, KCMF1, and PIKFYVE. Each is linked with PLEKHA3 in more than 16 cancer types. Because this analysis shows association rather than direction, both PLEKHA3-to-partner and partner-to-PLEKHA3 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, PLEKHA3 versus MAP3K2 in BONE, with a Pearson correlation of 0.67.

RNA expression associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PLEKHA3→partner) and Y-score (partner→PLEKHA3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	MAP3K2 →	+1.061	+1.306	<.001	<.001	3	17
UPPER_AERODIGESTIVE_TRACT	KCMF1 →	+1.147	+1.053	<.001	<.001	3	17
BLOOD_Lymphoma	PIKFYVE →	+1.313	+1.320	<.001	<.001	3	16
BONE	DR1 →	+1.077	+1.025	.001	.003	3	16
BONE	CREB1 →	+1.091	+0.878	<.001	.003	3	16
BLOOD_Leukemia	NCKAP1 →	+1.819	+0.632	<.001	<.001	3	15

Each partner links to its Q-omics profile. Showing the 6 strongest of 12,606 associations by consensus.

PLEKHA3 vs MAP3K2 — BONE

Explore this scatter interactively →