PLEKHA3

Across TCGA cell cohorts, PLEKHA3 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,695 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible PLEKHA3-associated GO terms across cancer lineages are Phosphatidylinositol biosynthetic process, Retrograde transport, endosome to Golgi, and Phosphatidylinositol metabolic process. Each is linked with PLEKHA3 in more than 18 cancer types. Because this analysis shows association rather than direction, both PLEKHA3-to-partner and partner-to-PLEKHA3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Phosphatidylinositol biosynthetic process grouped by PLEKHA3-low versus PLEKHA3-high in URINARY_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PLEKHA3→partner) and Y-score (partner→PLEKHA3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	Phosphatidylinositol biosynthetic process →	+0.062	+0.927	<.001	<.001	3	19
SOFT_TISSUE	Retrograde transport, endosome to Golgi →	+0.090	+1.309	<.001	<.001	3	17
SKIN	Phosphatidylinositol metabolic process →	+0.053	+1.101	<.001	<.001	3	17
UPPER_AERODIGESTIVE_TRACT	Endosomal transport →	+0.068	+1.081	.002	<.001	3	16
BONE	Regulation of transforming growth factor beta receptor signaling pathway →	+0.087	+1.004	<.001	.001	3	16
LIVER	Regulation of stress-activated MAPK cascade →	+0.147	+1.315	.002	.001	3	15

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,695 associations by consensus.

Phosphatidylinositol biosynthetic process by PLEKHA3 expression — URINARY_TRACT

Explore this box plot interactively →