PLEKHA3

Across TCGA cell cohorts, PLEKHA3 mutation is significantly associated with the RNA expression of many other genes, with 6 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible PLEKHA3-associated genes across cancer lineages are GSG1L2, EPPIN, and NKX2-6. Each is linked with PLEKHA3 in more than 1 cancer types. Because this analysis shows association rather than direction, both PLEKHA3-to-partner and partner-to-PLEKHA3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GSG1L2 grouped by PLEKHA3-low versus PLEKHA3-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PLEKHA3→partner) and Y-score (partner→PLEKHA3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	GSG1L2 →	+0.016	+4.437	<.001	.004	3	1
BLOOD_Leukemia	EPPIN →	+0.006	+4.922	.005	.009	3	1
BLOOD_Leukemia	NKX2-6 →	+0.639	+5.201	<.001	.006	3	1
BLOOD_Leukemia	OR52E4 →	+0.012	+5.201	.008	.006	3	1
BLOOD_Leukemia	OC90 →	+0.013	+5.201	<.001	.006	3	1
BLOOD_Leukemia	OR1D4 →	+0.062	+5.539	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 6 associations by consensus.

GSG1L2 by PLEKHA3 expression — LARGE_INTESTINE

Explore this box plot interactively →