PLEKHA2

Across TCGA patient cohorts, PLEKHA2 RNA expression is significantly associated with the protein abundance of many other proteins, with 7,919 significant associations in total. PDAC shows the largest number of these associations.

The most reproducible PLEKHA2-associated proteins across cancer lineages are PLEKHA2_S314, PLEKHA2_S401, and PLPBP. Each is linked with PLEKHA2 in more than 5 cancer types. Because this analysis shows association rather than direction, both PLEKHA2-to-partner and partner-to-PLEKHA2 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, PLEKHA2 versus PLEKHA2_S314 in PDAC, with a Pearson correlation of 0.43.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (PLEKHA2→partner) and Y-score (partner→PLEKHA2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	PLEKHA2_S314 →	+0.726	+0.345	.002	<.001	3	6
BRCA	PLEKHA2_S401 →	+1.014	+0.808	<.001	<.001	3	5
LSCC	PLPBP →	+0.505	+0.658	<.001	.003	3	4
COAD	NFATC2 →	+0.744	+0.434	.004	.001	3	4
OV	TACC1 →	+0.334	+0.459	<.001	.005	2	5
LSCC	ADAM9 →	+0.457	+0.721	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 7,919 associations by consensus.

PLEKHA2 vs PLEKHA2_S314 — PDAC

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