PLEKHA2

Across TCGA patient cohorts, PLEKHA2 protein abundance is significantly associated with the RNA expression of many other genes, with 9,011 significant associations in total. LUAD shows the largest number of these associations.

The most reproducible PLEKHA2-associated genes across cancer lineages are TACC1, HTRA4, and TFEC. Each is linked with PLEKHA2 in more than 6 cancer types. Because this analysis shows association rather than direction, both PLEKHA2-to-partner and partner-to-PLEKHA2 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, PLEKHA2 versus TACC1 in LSCC, with a Pearson correlation of 0.74.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PLEKHA2→partner) and Y-score (partner→PLEKHA2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	TACC1 →	+0.945	+0.377	<.001	<.001	3	7
BRCA	HTRA4 →	+0.671	+0.322	<.001	<.001	3	6
BRCA	TFEC →	+1.114	+0.532	<.001	<.001	3	6
BRCA	CD69 →	+1.247	+0.489	<.001	<.001	3	6
GBM	GPR65 →	+0.790	+0.209	.002	.002	3	6
BRCA	ADAM9 →	+0.878	+0.351	.002	.004	2	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 9,011 associations by consensus.

PLEKHA2 vs TACC1 — LSCC

Explore this scatter interactively →