PLEKHA2

Across TCGA patient cohorts, PLEKHA2 mutation is significantly associated with the RNA expression of many other genes, with 199 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PLEKHA2-associated genes across cancer lineages are RNU1-28P, COMMD4P2, and CFTR-AS1. Each is linked with PLEKHA2 in more than 2 cancer types. Because this analysis shows association rather than direction, both PLEKHA2-to-partner and partner-to-PLEKHA2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU1-28P grouped by PLEKHA2-low versus PLEKHA2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PLEKHA2→partner) and Y-score (partner→PLEKHA2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RNU1-28P →	+0.318	+3.262	.001	.006	3	3
KIRC	COMMD4P2 →	+0.149	+5.442	<.001	.005	3	2
LUSC	CFTR-AS1 →	+0.461	+5.273	<.001	.006	3	2
COAD	NPM1P36 →	+0.118	+3.902	.005	.004	3	1
COAD	SOD1P1 →	+0.153	+3.636	<.001	.006	3	1
COAD	PRPF4BP1 →	+0.280	+3.569	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 199 associations by consensus.

RNU1-28P by PLEKHA2 expression — UCEC

Explore this box plot interactively →