PLEKHA2

Across TCGA cell cohorts, PLEKHA2 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,940 significant associations in total. SOFT_TISSUE shows the largest number of these associations.

The most reproducible PLEKHA2-associated GO terms across cancer lineages are Regulation of protein K48-linked ubiquitination, Regulation of macrophage fusion, and Positive regulation of macrophage fusion. Each is linked with PLEKHA2 in more than 11 cancer types. Because this analysis shows association rather than direction, both PLEKHA2-to-partner and partner-to-PLEKHA2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of protein K48-linked ubiquitination grouped by PLEKHA2-low versus PLEKHA2-high in KIDNEY.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PLEKHA2→partner) and Y-score (partner→PLEKHA2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	Regulation of protein K48-linked ubiquitination →	+0.142	+1.727	<.001	.004	3	12
UPPER_AERODIGESTIVE_TRACT	Regulation of macrophage fusion →	+0.372	+1.410	<.001	<.001	3	12
UPPER_AERODIGESTIVE_TRACT	Positive regulation of macrophage fusion →	+0.372	+1.410	<.001	<.001	3	12
LUNG_NSCLC_LUSC	Positive regulation of cell-substrate adhesion →	+0.116	+1.411	.002	.002	3	11
OVARY	Caveola assembly →	+0.166	+1.411	<.001	<.001	3	11
SOFT_TISSUE	Maintenance of protein location in cell →	+0.106	+1.186	<.001	<.001	3	11

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,940 associations by consensus.

Regulation of protein K48-linked ubiquitination by PLEKHA2 expression — KIDNEY

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