PLEKHA2

Across TCGA cell cohorts, PLEKHA2 mutation is significantly associated with the RNA expression of many other genes, with 8 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PLEKHA2-associated genes across cancer lineages are ECE2, GALP, and IQCF6. Each is linked with PLEKHA2 in more than 1 cancer types. Because this analysis shows association rather than direction, both PLEKHA2-to-partner and partner-to-PLEKHA2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ECE2 grouped by PLEKHA2-low versus PLEKHA2-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PLEKHA2→partner) and Y-score (partner→PLEKHA2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	ECE2 →	+0.319	+4.054	<.001	.004	3	1
LARGE_INTESTINE	GALP →	+0.016	+4.437	<.001	.004	3	1
LARGE_INTESTINE	IQCF6 →	+0.279	+4.882	<.001	<.001	3	1
LARGE_INTESTINE	NEXMIF →	+0.243	+4.196	<.001	.002	3	1
LARGE_INTESTINE	F11 →	+0.068	+4.882	<.001	<.001	3	1
BLOOD_Leukemia	SCGB2A1 →	+0.054	+5.201	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 8 associations by consensus.

ECE2 by PLEKHA2 expression — LARGE_INTESTINE

Explore this box plot interactively →