PLEKHA1

Across TCGA patient cohorts, PLEKHA1 RNA expression is significantly associated with the protein abundance of many other proteins, with 16,642 significant associations in total. GBM shows the largest number of these associations.

The most reproducible PLEKHA1-associated proteins across cancer lineages are PLEKHA1_S380, PTPN1, and PLEKHA1_S129. Each is linked with PLEKHA1 in more than 6 cancer types. Because this analysis shows association rather than direction, both PLEKHA1-to-partner and partner-to-PLEKHA1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, PLEKHA1 versus PLEKHA1_S380 in LSCC, with a Pearson correlation of 0.59.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (PLEKHA1→partner) and Y-score (partner→PLEKHA1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	PLEKHA1_S380 →	+1.269	+1.119	<.001	<.001	3	6
BRCA	PTPN1 →	-0.308	-0.333	.001	.008	2	7
LSCC	PLEKHA1_S129 →	+1.605	+1.025	<.001	<.001	3	5
GBM	SAMHD1_S33 →	-0.677	-0.361	<.001	.001	3	5
LSCC	ABLIM1_S367 →	+0.628	+0.765	.002	<.001	3	5
LUAD	MAPKAPK3 →	-0.355	-0.615	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 16,642 associations by consensus.

PLEKHA1 vs PLEKHA1_S380 — LSCC

Explore this scatter interactively →