PLEKHA1

Across TCGA patient cohorts, PLEKHA1 protein abundance is significantly associated with the RNA expression of many other genes, with 14,311 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible PLEKHA1-associated genes across cancer lineages are BTBD16, BTRC, and CD86. Each is linked with PLEKHA1 in more than 6 cancer types. Because this analysis shows association rather than direction, both PLEKHA1-to-partner and partner-to-PLEKHA1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, PLEKHA1 versus BTBD16 in CCRCC, with a Pearson correlation of 0.54.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PLEKHA1→partner) and Y-score (partner→PLEKHA1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	BTBD16 →	+0.815	+0.342	<.001	<.001	3	7
LSCC	BTRC →	+0.434	+0.719	<.001	<.001	3	6
OV	CD86 →	-1.171	-0.752	.002	.007	3	5
HNSC	CD80 →	-0.831	-0.399	<.001	<.001	3	5
HNSC	DNMBP →	+0.650	+0.387	<.001	<.001	3	5
UCEC	ATE1 →	+0.553	+0.486	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 14,311 associations by consensus.

PLEKHA1 vs BTBD16 — CCRCC

Explore this scatter interactively →