PLEKHA1

Across TCGA cell cohorts, PLEKHA1 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,144 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PLEKHA1-associated GO terms across cancer lineages are Glycerophospholipid metabolic process, Positive regulation of cytoplasmic mRNA processing body assembly, and Golgi vesicle budding. Each is linked with PLEKHA1 in more than 8 cancer types. Because this analysis shows association rather than direction, both PLEKHA1-to-partner and partner-to-PLEKHA1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Glycerophospholipid metabolic process grouped by PLEKHA1-low versus PLEKHA1-high in STOMACH.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PLEKHA1→partner) and Y-score (partner→PLEKHA1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	Glycerophospholipid metabolic process →	+0.042	+1.559	<.001	<.001	3	9
UPPER_AERODIGESTIVE_TRACT	Positive regulation of cytoplasmic mRNA processing body assembly →	+0.098	+0.843	.001	.004	3	9
LUNG_SCLC	Golgi vesicle budding →	+0.108	+1.047	.002	.002	3	9
OESOPHAGUS	Copper ion export →	-0.183	-0.832	.005	.006	3	9
LUNG_SCLC	Nuclear-transcribed mRNA poly(A) tail shortening →	+0.074	+0.778	.001	.005	3	9
LARGE_INTESTINE	Regulation of syncytium formation by plasma membrane fusion →	+0.085	+0.822	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,144 associations by consensus.

Glycerophospholipid metabolic process by PLEKHA1 expression — STOMACH

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