PLEKHA1

Across TCGA cell cohorts, PLEKHA1 mutation is significantly associated with the RNA expression of many other genes, with 8 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible PLEKHA1-associated genes across cancer lineages are BRDT, BHMT, and CALHM4. Each is linked with PLEKHA1 in more than 1 cancer types. Because this analysis shows association rather than direction, both PLEKHA1-to-partner and partner-to-PLEKHA1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, BRDT grouped by PLEKHA1-low versus PLEKHA1-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PLEKHA1→partner) and Y-score (partner→PLEKHA1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	BRDT →	+0.147	+4.342	<.001	.002	3	1
BLOOD_Leukemia	BHMT →	+0.153	+3.745	<.001	.005	3	1
BLOOD_Leukemia	CALHM4 →	+0.024	+3.684	<.001	.004	3	1
BLOOD_Leukemia	OR13H1 →	+0.090	+3.475	<.001	.006	3	1
BLOOD_Leukemia	PROP1 →	+0.020	+3.289	.001	.009	3	1
BLOOD_Leukemia	TSSK1B →	+0.007	+3.289	.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 8 associations by consensus.

BRDT by PLEKHA1 expression — BLOOD_Leukemia

Explore this box plot interactively →