PLEK2

Across TCGA patient cohorts, PLEK2 mutation is significantly associated with the RNA expression of many other genes, with 562 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PLEK2-associated genes across cancer lineages are MIR3173, OR10A7, and MIR190B. Each is linked with PLEK2 in more than 1 cancer types. Because this analysis shows association rather than direction, both PLEK2-to-partner and partner-to-PLEK2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR3173 grouped by PLEK2-low versus PLEK2-high in LIHC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PLEK2→partner) and Y-score (partner→PLEK2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIHC	MIR3173 →	+0.717	+5.447	<.001	.005	3	2
LIHC	OR10A7 →	+0.177	+5.758	<.001	.003	3	2
LIHC	MIR190B →	+0.413	+6.008	<.001	.002	3	2
BLCA	RPL36AP35 →	+0.184	+7.640	<.001	.009	3	2
UCEC	DEFB105A →	+0.042	+3.923	<.001	.009	3	2
UCEC	RN7SL98P →	+0.114	+2.845	.007	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 562 associations by consensus.

MIR3173 by PLEK2 expression — LIHC

Explore this box plot interactively →