PLEK2

Across TCGA patient cohorts, PLEK2 mutation is significantly associated with the total protein of many other genes, with 7 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PLEK2-associated genes across cancer lineages are MEK1, Notch1, and Paxillin. Each is linked with PLEK2 in more than 1 cancer types. Because this analysis shows association rather than direction, both PLEK2-to-partner and partner-to-PLEK2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MEK1 grouped by PLEK2-low versus PLEK2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PLEK2→partner) and Y-score (partner→PLEK2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MEK1 →	+0.495	+3.169	.013	.019	3	1
UCEC	Notch1 →	+0.223	+2.820	.003	.035	3	1
UCEC	Paxillin →	+0.328	+3.009	.021	.019	3	1
UCEC	EGFR_pY1068 →	-0.304	-3.169	.027	.020	2	1
UCEC	Tuberin →	+0.387	+3.169	.008	.020	2	1
UCEC	VEGFR2 →	+0.381	+2.817	.019	.036	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 7 associations by consensus.

MEK1 by PLEK2 expression — UCEC

Explore this box plot interactively →