PLEC

Across TCGA patient cohorts, PLEC RNA expression is significantly associated with the RNA expression of many other genes, with 18,910 significant associations in total. ACC shows the largest number of these associations.

The most reproducible PLEC-associated genes across cancer lineages are BCL9L, CDC42BPB, and SCRIB. Each is linked with PLEC in more than 33 cancer types. Because this analysis shows association rather than direction, both PLEC-to-partner and partner-to-PLEC results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, PLEC versus BCL9L in DLBC, with a Pearson correlation of 0.75.

RNA expression associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PLEC→partner) and Y-score (partner→PLEC) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
DLBC	BCL9L →	+1.860	+1.193	<.001	<.001	3	34
DLBC	CDC42BPB →	+1.212	+0.998	<.001	<.001	3	34
OV	SCRIB →	+1.089	+1.376	<.001	<.001	3	33
SCLC	ZNF707 →	+1.850	+1.331	<.001	.003	3	33
ACC	AP2A1 →	+0.767	+0.778	<.001	<.001	3	33
CHOL	MYH9 →	+1.341	+1.371	<.001	<.001	3	33

Each partner links to its Q-omics profile. Showing the 6 strongest of 18,910 associations by consensus.

PLEC vs BCL9L — DLBC

Explore this scatter interactively →