PLEC

Across TCGA patient cohorts, PLEC RNA expression is significantly associated with the protein abundance of many other proteins, with 9,121 significant associations in total. LUAD shows the largest number of these associations.

The most reproducible PLEC-associated proteins across cancer lineages are PLEC_S4231, PLEC_S4382, and PLEC_T2735. Each is linked with PLEC in more than 6 cancer types. Because this analysis shows association rather than direction, both PLEC-to-partner and partner-to-PLEC results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, PLEC versus PLEC_S4231 in PDAC, with a Pearson correlation of 0.44.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (PLEC→partner) and Y-score (partner→PLEC) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	PLEC_S4231 →	+0.663	+0.735	<.001	<.001	3	7
PDAC	PLEC_S4382 →	+0.663	+0.735	<.001	<.001	3	7
LSCC	PLEC_T2735 →	+0.676	+0.878	<.001	<.001	3	6
LSCC	PLEC_T2886 →	+0.676	+0.878	<.001	<.001	3	6
CCRCC	C1R →	+0.628	+0.787	<.001	<.001	3	5
LUAD	PLEC_S4467 →	+0.862	+0.923	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 9,121 associations by consensus.

PLEC vs PLEC_S4231 — PDAC

Explore this scatter interactively →