PLEC

Across TCGA patient cohorts, PLEC mutation is significantly associated with the total protein of many other genes, with 125 significant associations in total. COAD shows the largest number of these associations.

The most reproducible PLEC-associated genes across cancer lineages are Caspase-7-cleavedD198, eIF4E, and Cyclin-B1. Each is linked with PLEC in more than 6 cancer types. Because this analysis shows association rather than direction, both PLEC-to-partner and partner-to-PLEC results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by PLEC-low versus PLEC-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PLEC→partner) and Y-score (partner→PLEC) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	Caspase-7-cleavedD198 →	+1.036	+3.186	<.001	<.001	3	7
UCEC	eIF4E →	+0.155	+1.273	.002	.006	3	5
UCEC	Cyclin-B1 →	+0.446	+1.426	<.001	<.001	3	5
COAD	Cyclin-E2 →	+0.175	+3.906	.010	<.001	3	5
UCEC	PCNA →	+0.200	+1.187	<.001	.001	3	5
COAD	Stathmin →	+0.154	+1.467	<.001	.007	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 125 associations by consensus.

Caspase-7-cleavedD198 by PLEC expression — COAD

Explore this box plot interactively →