PLEC

Across TCGA cell cohorts, PLEC RNA expression is significantly associated with the go_rna of many other GO terms, with 5,599 significant associations in total. BONE shows the largest number of these associations.

The most reproducible PLEC-associated GO terms across cancer lineages are Regulation of fibroblast proliferation, Fibroblast migration, and Regulation of cell-matrix adhesion. Each is linked with PLEC in more than 18 cancer types. Because this analysis shows association rather than direction, both PLEC-to-partner and partner-to-PLEC results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of fibroblast proliferation grouped by PLEC-low versus PLEC-high in PANCREAS.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PLEC→partner) and Y-score (partner→PLEC) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	Regulation of fibroblast proliferation →	+0.113	+1.171	<.001	<.001	3	19
LIVER	Fibroblast migration →	+0.234	+1.552	.001	.001	3	18
BONE	Regulation of cell-matrix adhesion →	+0.181	+2.499	<.001	<.001	3	17
BONE	Actomyosin contractile ring assembly actin filament organization →	+0.265	+1.957	<.001	<.001	3	17
BONE	Hemidesmosome assembly →	+0.403	+1.807	<.001	<.001	3	17
BONE	Peripheral nervous system myelin maintenance →	+0.329	+2.017	<.001	<.001	3	17

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,599 associations by consensus.

Regulation of fibroblast proliferation by PLEC expression — PANCREAS

Explore this box plot interactively →