PLEC

Across TCGA cell cohorts, PLEC mutation is significantly associated with the RNA expression of many other genes, with 2,262 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PLEC-associated genes across cancer lineages are FUT10, CRACD, and ASTN2. Each is linked with PLEC in more than 4 cancer types. Because this analysis shows association rather than direction, both PLEC-to-partner and partner-to-PLEC results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FUT10 grouped by PLEC-low versus PLEC-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PLEC→partner) and Y-score (partner→PLEC) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	FUT10 →	+0.776	+1.936	<.001	<.001	3	5
BLOOD_Leukemia	CRACD →	+0.827	+1.231	.009	.005	3	4
LARGE_INTESTINE	ASTN2 →	+0.643	+1.686	<.001	<.001	3	4
LARGE_INTESTINE	GLOD4 →	+0.609	+1.544	<.001	<.001	3	4
LARGE_INTESTINE	TUBGCP5 →	+0.458	+1.244	.001	.001	3	4
STOMACH	ZNF596 →	+0.730	+3.263	.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,262 associations by consensus.

FUT10 by PLEC expression — LARGE_INTESTINE

Explore this box plot interactively →