PLD6

Across TCGA patient cohorts, PLD6 mutation is significantly associated with the RNA expression of many other genes, with 121 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PLD6-associated genes across cancer lineages are RNA5SP124, PTP4A1P7, and RPL35AP33. Each is linked with PLD6 in more than 1 cancer types. Because this analysis shows association rather than direction, both PLD6-to-partner and partner-to-PLD6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNA5SP124 grouped by PLD6-low versus PLD6-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PLD6→partner) and Y-score (partner→PLD6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RNA5SP124 →	+0.859	+4.166	<.001	<.001	3	2
UCEC	PTP4A1P7 →	+0.203	+3.130	.005	.003	3	2
UCEC	RPL35AP33 →	+0.240	+2.798	.001	.008	3	2
UCEC	FBLIM1P2 →	+0.271	+3.339	<.001	.002	3	2
UCEC	ATP6V1E1P2 →	+0.465	+3.813	<.001	<.001	3	2
BRCA	MIR6089 →	+0.627	+6.505	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 121 associations by consensus.

RNA5SP124 by PLD6 expression — UCEC

Explore this box plot interactively →