PLD5

Across TCGA patient cohorts, PLD5 RNA expression is significantly associated with the go_rna of many other GO terms, with 7,155 significant associations in total. STAD shows the largest number of these associations.

The most reproducible PLD5-associated GO terms across cancer lineages are Epithelial to mesenchymal transition, Mesenchymal cell differentiation, and Positive regulation of Arp2/3 complex-mediated actin nucleation. Each is linked with PLD5 in more than 20 cancer types. Because this analysis shows association rather than direction, both PLD5-to-partner and partner-to-PLD5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Epithelial to mesenchymal transition grouped by PLD5-low versus PLD5-high in STAD.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PLD5→partner) and Y-score (partner→PLD5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STAD	Epithelial to mesenchymal transition →	+0.064	+0.152	<.001	<.001	3	21
STAD	Mesenchymal cell differentiation →	+0.062	+0.192	<.001	<.001	3	21
STAD	Positive regulation of Arp2/3 complex-mediated actin nucleation →	+0.074	+0.201	<.001	<.001	3	20
ESCA	Regulation of epithelial to mesenchymal transition →	+0.068	+0.240	<.001	.001	2	20
STAD	Smooth muscle cell migration →	+0.075	+0.209	<.001	<.001	3	19
STAD	Actomyosin structure organization →	+0.064	+0.146	<.001	<.001	3	19

Each partner links to its Q-omics profile. Showing the 6 strongest of 7,155 associations by consensus.

Epithelial to mesenchymal transition by PLD5 expression — STAD

Explore this box plot interactively →