PLD5

Across TCGA patient cohorts, PLD5 mutation is significantly associated with the RNA expression of many other genes, with 3,067 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PLD5-associated genes across cancer lineages are GLRX5, SETD3, and HAUS2. Each is linked with PLD5 in more than 3 cancer types. Because this analysis shows association rather than direction, both PLD5-to-partner and partner-to-PLD5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GLRX5 grouped by PLD5-low versus PLD5-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PLD5→partner) and Y-score (partner→PLD5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	GLRX5 →	+0.361	+3.361	.005	.004	3	4
COAD	SETD3 →	+0.446	+3.351	.001	.005	3	4
UCEC	HAUS2 →	+0.596	+1.999	<.001	<.001	3	4
COAD	CDCA2 →	+0.826	+3.479	<.001	.002	3	3
COAD	ERCC6L →	+0.701	+3.598	<.001	.001	3	3
SKCM	MCMBP →	+0.538	+3.334	.002	.005	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,067 associations by consensus.

GLRX5 by PLD5 expression — COAD

Explore this box plot interactively →