PLD5

Across TCGA patient cohorts, PLD5 mutation is significantly associated with the total protein of many other genes, with 39 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PLD5-associated genes across cancer lineages are Caspase-7-cleavedD198, ASNS, and VHL. Each is linked with PLD5 in more than 2 cancer types. Because this analysis shows association rather than direction, both PLD5-to-partner and partner-to-PLD5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by PLD5-low versus PLD5-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PLD5→partner) and Y-score (partner→PLD5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Caspase-7-cleavedD198 →	+0.432	+1.697	.022	.012	3	3
COAD	ASNS →	+0.791	+2.330	<.001	.020	3	2
SKCM	VHL →	-0.823	-3.459	.016	.005	3	2
UCEC	EGFR_pY1068 →	-0.184	-1.765	.021	.013	3	2
UCEC	JNK2 →	+0.148	+1.727	.019	.023	3	2
UCEC	Ku80 →	+0.235	+1.790	.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 39 associations by consensus.

Caspase-7-cleavedD198 by PLD5 expression — UCEC

Explore this box plot interactively →