PLD5

Across TCGA cell cohorts, PLD5 RNA expression is significantly associated with the go_rna of many other GO terms, with 1,659 significant associations in total. BONE shows the largest number of these associations.

The most reproducible PLD5-associated GO terms across cancer lineages are NADH dehydrogenase complex assembly, Mitochondrial respiratory chain complex I assembly, and Retinoic acid receptor signaling pathway. Each is linked with PLD5 in more than 4 cancer types. Because this analysis shows association rather than direction, both PLD5-to-partner and partner-to-PLD5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, NADH dehydrogenase complex assembly grouped by PLD5-low versus PLD5-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PLD5→partner) and Y-score (partner→PLD5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	NADH dehydrogenase complex assembly →	+0.120	+1.459	<.001	.001	3	5
BONE	Mitochondrial respiratory chain complex I assembly →	+0.120	+1.459	<.001	.001	3	5
SOFT_TISSUE	Retinoic acid receptor signaling pathway →	-0.098	-0.927	<.001	<.001	3	4
LUNG_SCLC	Trans-synaptic signaling by trans-synaptic complex, modulating synaptic transmission →	+0.680	+1.280	.004	.001	3	4
BLOOD_Leukemia	Outflow tract septum morphogenesis →	-0.101	-0.047	.001	.002	3	4
SOFT_TISSUE	Cardiac ventricle development →	-0.081	-0.951	.003	.004	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,659 associations by consensus.

NADH dehydrogenase complex assembly by PLD5 expression — BONE

Explore this box plot interactively →