PLD5

Across TCGA cell cohorts, PLD5 mutation is significantly associated with the RNA expression of many other genes, with 155 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PLD5-associated genes across cancer lineages are SLC17A2, FOXB2, and IZUMO3. Each is linked with PLD5 in more than 1 cancer types. Because this analysis shows association rather than direction, both PLD5-to-partner and partner-to-PLD5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SLC17A2 grouped by PLD5-low versus PLD5-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PLD5→partner) and Y-score (partner→PLD5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	SLC17A2 →	+0.012	+5.266	<.001	.001	3	1
LUNG_NSCLC_LUAD	FOXB2 →	+1.247	+5.266	<.001	.001	3	1
LUNG_NSCLC_LUAD	IZUMO3 →	+0.032	+4.947	<.001	.001	3	1
SKIN	SCRT2 →	+0.006	+4.095	<.001	.009	3	1
LARGE_INTESTINE	SEC14L3 →	+0.023	+2.894	<.001	.001	3	1
LARGE_INTESTINE	RHOXF1 →	+0.226	+3.559	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 155 associations by consensus.

SLC17A2 by PLD5 expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →