PLD4

Across TCGA patient cohorts, PLD4 mutation is significantly associated with the total protein of many other genes, with 21 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PLD4-associated genes across cancer lineages are eEF2, A-Raf_pS299, and JNK2. Each is linked with PLD4 in more than 1 cancer types. Because this analysis shows association rather than direction, both PLD4-to-partner and partner-to-PLD4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eEF2 grouped by PLD4-low versus PLD4-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PLD4→partner) and Y-score (partner→PLD4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eEF2 →	+0.323	+3.321	.028	.009	3	1
UCEC	A-Raf_pS299 →	-0.123	-3.169	.012	.019	3	1
UCEC	JNK2 →	+0.307	+3.196	<.001	.009	3	1
UCEC	MEK1 →	+0.488	+3.459	.001	.005	3	1
UCEC	MSH2 →	-0.263	-2.973	.005	.035	3	1
UCEC	N-Cadherin →	+0.176	+2.999	.044	.035	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 21 associations by consensus.

eEF2 by PLD4 expression — UCEC

Explore this box plot interactively →