PLD4

Across TCGA cell cohorts, PLD4 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,507 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible PLD4-associated GO terms across cancer lineages are Negative regulation of myoblast fusion, Negative regulation of syncytium formation by plasma membrane fusion, and Regulation of myoblast fusion. Each is linked with PLD4 in more than 9 cancer types. Because this analysis shows association rather than direction, both PLD4-to-partner and partner-to-PLD4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of myoblast fusion grouped by PLD4-low versus PLD4-high in LARGE_INTESTINE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PLD4→partner) and Y-score (partner→PLD4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	Negative regulation of myoblast fusion →	+0.098	+0.143	<.001	<.001	3	10
LARGE_INTESTINE	Negative regulation of syncytium formation by plasma membrane fusion →	+0.090	+0.112	<.001	<.001	3	10
LARGE_INTESTINE	Regulation of myoblast fusion →	+0.081	+0.108	<.001	<.001	3	8
BLOOD_Lymphoma	Viral translational termination-reinitiation →	+0.079	+2.343	<.001	.001	3	8
URINARY_TRACT	Regulation of ERBB signaling pathway →	+0.067	+0.155	<.001	<.001	3	8
LARGE_INTESTINE	Cytoplasmic translation →	+0.058	+0.110	<.001	.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,507 associations by consensus.

Negative regulation of myoblast fusion by PLD4 expression — LARGE_INTESTINE

Explore this box plot interactively →