PLD3

Across TCGA patient cohorts, PLD3 mutation is significantly associated with the RNA expression of many other genes, with 3,718 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PLD3-associated genes across cancer lineages are MIR6769B, RNA5SP411, and KRTAP19-8. Each is linked with PLD3 in more than 1 cancer types. Because this analysis shows association rather than direction, both PLD3-to-partner and partner-to-PLD3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR6769B grouped by PLD3-low versus PLD3-high in BRCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PLD3→partner) and Y-score (partner→PLD3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	MIR6769B →	+0.341	+6.293	<.001	<.001	3	2
UCEC	RNA5SP411 →	+1.206	+2.171	<.001	<.001	3	2
BRCA	KRTAP19-8 →	+0.183	+5.009	.002	<.001	3	2
BRCA	RBMY2OP →	+0.019	+7.057	<.001	.009	3	2
CESC	RNU6-128P →	+0.398	+5.306	<.001	.006	3	2
CESC	MIR1827 →	+0.516	+5.306	<.001	.006	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,718 associations by consensus.

MIR6769B by PLD3 expression — BRCA

Explore this box plot interactively →