PLD3

Across TCGA patient cohorts, PLD3 mutation is significantly associated with the total protein of many other genes, with 32 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PLD3-associated genes across cancer lineages are Notch1, ATM, and EGFR_pY1068. Each is linked with PLD3 in more than 1 cancer types. Because this analysis shows association rather than direction, both PLD3-to-partner and partner-to-PLD3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Notch1 grouped by PLD3-low versus PLD3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PLD3→partner) and Y-score (partner→PLD3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Notch1 →	+0.189	+2.128	<.001	.009	3	2
UCEC	ATM →	-0.466	-1.678	.007	.023	3	2
UCEC	EGFR_pY1068 →	-0.280	-2.087	.003	.005	3	1
UCEC	A-Raf_pS299 →	-0.196	-2.807	<.001	.003	3	1
UCEC	ACC1 →	+0.370	+2.335	.007	.018	3	1
UCEC	JNK2 →	+0.299	+2.486	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 32 associations by consensus.

Notch1 by PLD3 expression — UCEC

Explore this box plot interactively →