PLD3

Across TCGA cell cohorts, PLD3 mutation is significantly associated with the RNA expression of many other genes, with 28 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible PLD3-associated genes across cancer lineages are DEFA6, LCE6A, and OR1E2. Each is linked with PLD3 in more than 1 cancer types. Because this analysis shows association rather than direction, both PLD3-to-partner and partner-to-PLD3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DEFA6 grouped by PLD3-low versus PLD3-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PLD3→partner) and Y-score (partner→PLD3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	DEFA6 →	+0.264	+4.977	<.001	.007	3	1
SKIN	LCE6A →	+0.530	+6.022	<.001	.001	3	1
CNS	OR1E2 →	+0.341	+4.321	<.001	.009	3	1
CNS	OR3A3 →	+0.374	+4.315	<.001	.006	3	1
CNS	OR1E1 →	+0.378	+4.321	<.001	.009	3	1
CNS	FCAR →	+0.051	+4.472	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 28 associations by consensus.

DEFA6 by PLD3 expression — SKIN

Explore this box plot interactively →