PLD3

Across TCGA cell cohorts, PLD3 mutation is significantly associated with the mutation status of many other genes, with 2,494 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible PLD3-associated genes across cancer lineages are SPG7, TCF20, and THBS2. Each is linked with PLD3 in more than 3 cancer types. Because this analysis shows association rather than direction, both PLD3-to-partner and partner-to-PLD3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SPG7 grouped by PLD3-low versus PLD3-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PLD3→partner) and Y-score (partner→PLD3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	SPG7 →	+4.392	+4.392	.009	.009	1	4
CNS	TCF20 →	+5.000	+4.044	.008	.008	1	4
OVARY	THBS2 →	+4.415	+4.977	.007	.007	1	4
LARGE_INTESTINE	PCDHGB3 →	+2.080	+3.906	.003	.003	1	4
BLOOD_Leukemia	ARVCF →	+2.341	+2.638	.009	.009	1	4
BLOOD_Leukemia	MPO →	+3.662	+3.523	<.001	<.001	1	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,494 associations by consensus.

SPG7 by PLD3 expression — SKIN

Explore this box plot interactively →